What is creatinine? Why it can measure kidney function?

Creatinine is one of the external symptoms of kidney damage, kidney inherent cell damage, glomerular sclerosis, fibrosis, kidney unit structure is destroyed, can not effectively play the filtration function. Creatinine and other toxins causing substances accumulate in the body, resulting in a high creatinine and, therefore, different creatinine values ​​represent the severity of the patient or not, and in accordance with the level of creatinine people will be divided into different stages of kidney disease, so creatinine and kidney disease closely related.

Creatinine is a metabolic product of human muscle. In muscle, creatine primarily through irreversible non-enzymatic dehydration reaction slowly generate creatinine, and then released into the blood with the urine excretion. Creatinine increased and therefore the total body muscle closely, substantially unaffected by diet, high catabolism and other extra-renal factors, exogenous creatinine intake is stable, the amount of in vivo constant (daily 20mg / kg) in the case, creatinine concentration depends mainly on the glomerular filtration rate.

When the glomerular filtration rate to more than 50% of normal, creatinine began to rapidly increase, so when creatinine was significantly higher than normal, often expressed in renal function has been severely compromised.


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